Cathepsin H Protein (CTSH) (AA 22-333) (His tag)

Catalog No. ABIN7320712

Product Details

Target: Cathepsin H (CTSH)

Protein Type: Recombinant

Protein Characteristics: AA 22-333

Origin: Mouse

Source: Human Cells

Purification tag / Conjugate: This Cathepsin H protein is labelled with His tag.

Purpose: Recombinant Mouse Cathepsin H/CTSH Protein (aa 22-333, His Tag)

Sequence: Glu22-Val333

Characteristics: Recombinant Mouse Cathepsin H is produced by our Mammalian expression system and the target gene encoding Glu22-Val333 is expressed with a 6His tag at the C-terminus.

Purity: > 95 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Cathepsin H (CTSH)

Alternative Name: Cathepsin H/CTSH (CTSH Products)

Synonyms: fc44c02 Protein, zgc:85774 Protein, wu:fc44c02 Protein, CTSH Protein, ACC-4 Protein, ACC-5 Protein, CPSB Protein, minichain Protein, AL022844 Protein, cathepsin H Protein, cathepsin H L homeolog Protein, ctsh Protein, CTSH Protein, ctsh.L Protein, Ctsh Protein

Background:

Background: Cathepsin H (CTSH), which can act both as an aminopeptidase and as an endopeptidase, is a lysosomal cysteine protease of the papain family. CTSH is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. CTSH is associated with various pathological conditions like human fibrous meningioma, colorectal cancer, arthritis, human prostate tumor and lung cancer. CTSH is associated with cancer progression because of their ability to degrade extracellular matrices facilitating invasion, angiogenesis and metastasis as is evident from numerous clinical reports and experimental models. The expression of CTSH is significantly increased in disease states such as in prostate tumors, sera of asthmatic patients, and mucosa of colorectal cancer patients.

Synonym: Pro-cathepsin H, CTSH, ACC-4, ACC-5, aleurain, cathepsin B3, cathepsin BA, cathepsin H, CPSB, minichain, N-benzoylarginine-beta-naphthylamide hydrolase

Molecular Weight: 36.1 kDa

Pathways: Positive Regulation of Endopeptidase Activity