CRABP2 Protein (His tag)
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- Target See all CRABP2 Proteins
- CRABP2 (Cellular Retinoic Acid Binding Protein 2 (CRABP2))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CRABP2 protein is labelled with His tag.
- Purpose
- Recombinant Human CRABP2 Protein (His Tag)
- Sequence
- Pro2-Glu 138
- Characteristics
- A DNA sequence encoding the human CRABP2 (NP_001869.1) (Pro2-Glu 138) was expressed, with a polyhistide tag at the N-terminus.
- Purity
- > 96 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CRABP2 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- CRABP2 (Cellular Retinoic Acid Binding Protein 2 (CRABP2))
- Alternative Name
- CRABP2 (CRABP2 Products)
- Synonyms
- crabp Protein, crabp2-A Protein, xCRABP Protein, xCRABP-b Protein, cb432 Protein, cb434 Protein, crabp2 Protein, sb:cb434 Protein, wu:fc51a11 Protein, zgc:110496 Protein, CRABP2 Protein, rbp6 Protein, MGC89469 Protein, crabp-ii Protein, CRABP-II Protein, RBP6 Protein, AI893628 Protein, Crabp-2 Protein, CrabpII Protein, im:7136989 Protein, cellular retinoic acid binding protein 2 L homeolog Protein, cellular retinoic acid binding protein 2, a Protein, cellular retinoic acid binding protein 2 Protein, cellular retinoic acid binding protein II Protein, cellular retinoic acid binding protein 2, b Protein, crabp2.L Protein, crabp2a Protein, CRABP2 Protein, crabp2 Protein, Crabp2 Protein, crabp2b Protein
- Background
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Background: Cellular retinoic acid-binding protein 2, also known as Cellular retinoic acid-binding protein II, CRABP-II and CRABP2, is a protein which belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. The predicted amino acid sequences of human CRABP1 and CRABP2 demonstrated a 99.3% and 93.5% identity to mouse CRABP1 and CRABP2, respectively. CRABP2 forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Expression of CRABP2, but not CRABP1 mRNA, was markedly increased (greater than 15-fold) by retinoic acid treatment of fibroblasts cultured from human skin, whereas no significant induction of CRABP2 mRNA was observed in human lung fibroblasts. CRABP2 transports retinoic acid to the nucleus. It regulates the access of retinoic acid to the nuclear retinoic acid receptors. CRABP2 is necessary for elastin induction by All-trans retinoic acid (ATRA) in MRC-5 cells. It is expressed at low levels in emphysema fibroblasts. This alteration in the retinoic acid signalling pathway in lung fibroblasts may contribute to the defect of alveolar repair in human pulmonary emphysema.
Synonym: CRABP-II;RBP6
- Molecular Weight
- 16.5 kDa
- NCBI Accession
- NP_001869
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