COLEC12 Protein (His tag)
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- Target See all COLEC12 Proteins
- COLEC12 (Collectin Sub-Family Member 12 (COLEC12))
- Protein Type
- Recombinant
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Origin
- Rat
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Source
- Baculovirus infected Insect Cells
- Purification tag / Conjugate
- This COLEC12 protein is labelled with His tag.
- Purpose
- Recombinant Rat CLP1/COLEC12 Protein (His Tag)
- Sequence
- Ala101-Leu742
- Characteristics
- A DNA sequence encoding the mature form of rat COLEC12 (Q4V885) (Ala101-Leu742) was expressed,with a polyhistide tag at the N-terminus.
- Purity
- > 99 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method
- Top Product
- Discover our top product COLEC12 Protein
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Collectin Sub-Family Member 12 (COLEC12) (AA 1-622) protein (GST tag)
COLEC12 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Collectin Sub-Family Member 12 (COLEC12) (AA 101-200) protein (GST tag)COLEC12 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Collectin Sub-Family Member 12 (COLEC12) (AA 59-742) protein (His tag)Crystallography grade COLEC12 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Collectin Sub-Family Member 12 (COLEC12) (AA 59-742) protein (His tag)Crystallography grade COLEC12 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Collectin Sub-Family Member 12 (COLEC12) (AA 1-742) protein (Strep Tag)Crystallography grade COLEC12 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Collectin Sub-Family Member 12 (COLEC12) (AA 1-742) protein (Strep Tag)Crystallography grade COLEC12 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Collectin Sub-Family Member 12 (COLEC12) protein (Myc-DYKDDDDK Tag)COLEC12 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- COLEC12 (Collectin Sub-Family Member 12 (COLEC12))
- Alternative Name
- CLP1/COLEC12 (COLEC12 Products)
- Synonyms
- COLEC12 Protein, CLP1 Protein, NSR2 Protein, SCARA4 Protein, SRCL Protein, CL-P1 Protein, Scara4 Protein, hm:zeh0853 Protein, id:ibd2826 Protein, sb:cb377 Protein, si:ch211-212m21.5 Protein, collectin subfamily member 12 Protein, collectin sub-family member 12 Protein, COLEC12 Protein, colec12 Protein, Colec12 Protein
- Background
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Background: CLP1, also known as COLEC12, is a scavenger receptor that displays several functions associated with host defense. It contains 1 C-type lectin domain and 3 collagen-like domains. CLP1 is strongly expressed in placenta and moderately expressed in heart, skeletal muscle, small intestine and lung. It promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. CLP1 mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. It binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. It binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). CLP1 may also play a role in the clearance of amyloid beta in Alzheimer disease.
Synonym: Clp1,Nsr2,COLEC12
- Molecular Weight
- 72.4 kDa
- UniProt
- Q4V885
- Pathways
- Activation of Innate immune Response
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