Cytochrome C Protein (His tag)
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- Target See all Cytochrome C (CYCS) Proteins
- Cytochrome C (CYCS) (Cytochrome C, Somatic (CYCS))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Cytochrome C protein is labelled with His tag.
- Purpose
- Recombinant Human Cytochrome C/CYCS Protein (His Tag)
- Sequence
- Gly2-Glu105
- Characteristics
- Recombinant Human Cytochrome C is produced by our E.coli expression system and the target gene encoding Gly2-Glu105 is expressed with a 6His tag at the C-terminus.
- Purity
- > 85 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product CYCS Protein
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM Tris, 0.15M NaCl, 20 % Glycerol, pH 8.0.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- Cytochrome C (CYCS) (Cytochrome C, Somatic (CYCS))
- Alternative Name
- Cytochrome C/CYCS (CYCS Products)
- Synonyms
- CYC Protein, HCS Protein, THC4 Protein, cyct Protein, cyc Protein, hcs Protein, CYCS Protein, cytc Protein, CYCSA Protein, CG17903 Protein, Cyt C Protein, Cyt c Protein, Cyt-c2 Protein, CytC-2 Protein, Cytc Protein, Cytc-p Protein, DC4 Protein, DMc01 Protein, Dmel\\CG17903 Protein, cyt c Protein, cyt c-p Protein, cyt-c-p Protein, cyt-c2 Protein, cyt.c Protein, cytochrome c Protein, dc4 Protein, pDMc01 Protein, wu:fk52b01 Protein, zgc:86706 Protein, ENSMUSG00000058927 Protein, cytochrome c, somatic Protein, cytochrome c, somatic S homeolog Protein, Cytochrome c proximal Protein, cytochrome c, somatic b Protein, cytochrome c, somatic pseudogene Protein, cytochrome c-like Protein, cytochrome c Protein, CYCS Protein, cycs.S Protein, cycs Protein, Cycs Protein, Cyt-c-p Protein, cycsb Protein, Gm10053 Protein, LOC100724240 Protein, CYC Protein, LOC100847700 Protein, LOC101107954 Protein, LOC106829744 Protein, LOC106992390 Protein, LOC102085712 Protein
- Background
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Background: Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as a central component of the electron transport chain in mitochondria. CYCS transfers electrons between Complexes III (Coenzyme Q - Cyt C reductase) and IV (Cyt C oxidase). CYCS plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of Cytochrome C to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Synonym: Cytochrome C, CYCS, CYC
- Molecular Weight
- 12.8 kDa
- UniProt
- P99999
- Pathways
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
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