ERP27 Protein (Fc Tag)

Catalog No. ABIN7317271

Product Details

Target: ERP27 (Endoplasmic Reticulum Protein 27 (ERP27))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This ERP27 protein is labelled with Fc Tag.

Purpose: Recombinant Human ERP27 Protein (Fc Tag)

Sequence: Glu26-Pro269

Characteristics: A DNA sequence encoding the human ERP27 (Q96DN0) (Glu26-Pro269) was fused with Fc region of mouse IgG at the C-terminus.

Purity: > 84 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: ERP27 (Endoplasmic Reticulum Protein 27 (ERP27))

Alternative Name: ERP27 (ERP27 Products)

Synonyms: C12orf46 Protein, PDIA8 Protein, 1810033M07Rik Protein, 1810047B09Rik Protein, RGD1565381 Protein, endoplasmic reticulum protein 27 Protein, ERP27 Protein, Erp27 Protein

Background:

Background: ERP27 contains 1 thioredoxin domain and is a noncatalytic member of the protein disulfide isomerase family. Protein disulfide isomerases (PDIs) constitute a family of structurally related enzymes which catalyze disulfide bonds formation, reduction, or isomerization of newly synthesized proteins in the lumen of the endoplasmic reticulum (ER). They act also as chaperones, and are, therefore, part of a quality-control system for the correct folding of the proteins in the same subcellular compartment. PDI has been found to have moderate effects (25-fold) on the rate of oxidative folding of proteins in vitro. Recombinant Human Protein Disulfide Isomerase is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. Recombinant PDI has been found to have moderate effects (25-fold) on the rate of oxidative folding of proteins in vitro. ERP27 is a widely expressed protein which localizes to the ER and may act as a protease, protein disulfide isomerase, thiol-disulfide oxidase or phospholipase. ERP27 doesn't contain a CXXC active site motif indicating that it is a catalytically redox-inactive member of the protein disulfide isomerase family.

Synonym: Endoplasmic Reticulum Resident Protein 27, ER Protein 27, ERp27, ERP27, C12orf46

Molecular Weight: 53.7 kDa

UniProt: Q96DN0