EXTL2 Protein (His tag)
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- Target See all EXTL2 Proteins
- EXTL2 (Exostoses (Multiple)-Like 2 (EXTL2))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- Human Cells
- Purification tag / Conjugate
- This EXTL2 protein is labelled with His tag.
- Purpose
- Recombinant Mouse Exostosin-Like 2/EXTL2 Protein (His Tag)
- Sequence
- Asn43-Met330
- Characteristics
- Recombinant Mouse Exostosin-like 2 is produced by our Mammalian expression system and the target gene encoding Asn43-Met330 is expressed with a 6His tag at the N-terminus.
- Purity
- > 95 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Exostoses (Multiple)-Like 2 (EXTL2) (AA 39-330) protein (GST tag)
EXTL2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Exostoses (Multiple)-Like 2 (EXTL2) (AA 44-330) protein (His tag)Crystallography grade EXTL2 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Exostoses (Multiple)-Like 2 (EXTL2) (AA 43-330) protein (His tag)Crystallography grade EXTL2 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Exostoses (Multiple)-Like 2 (EXTL2) (AA 1-330) protein (Strep Tag)Crystallography grade EXTL2 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Exostoses (Multiple)-Like 2 (EXTL2) (AA 1-330) protein (Strep Tag)Crystallography grade EXTL2 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Exostoses (Multiple)-Like 2 (EXTL2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)EXTL2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl, pH 8.0.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- EXTL2 (Exostoses (Multiple)-Like 2 (EXTL2))
- Alternative Name
- Exostosin-Like 2/EXTL2 (EXTL2 Products)
- Synonyms
- 3000001D04Rik Protein, AW146439 Protein, EXTR2 Protein, exostoses (multiple)-like 2 Protein, exostosin like glycosyltransferase 2 Protein, exostosin-like glycosyltransferase 2 Protein, Extl2 Protein, EXTL2 Protein
- Background
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Background: Exostosin-like 2 (EXTL2) is a member of the exostosin (EXT)-related family which contains five members: EXT1, EXT2, EXTL1, EXTL2, and EXTL3. Studies have shown that EXT gene family members have the activities of heparan sulfate-synthesizing glycosyltransferases. EXT1 and EXT2, which have been identified as causal genes for hereditary multiple exostoses, have HS-GlcAT-II and GlcNAcT-II activities. EXTL1 has GlcNAcT-II activity and EXTL3 has GlcNAcT-I and -II activities. EXTL2 has GlcNAcT-I and N-acetylgalactosaminyltransferase activities, and transfers a GlcNAc residue to the tetrasaccharide linkage region when this region is phosphorylated by a xylose kinase 1 (FAM20B) and thereby terminate chain elongation. In mice, lack of EXTL2 causes glycosaminoglycan (GAG) overproduction and structural changes of GAGs associated with pathological processes.
Synonym: Exostosin-like 2, Extl2, Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, Alpha-GalNAcT EXTL2, EXT-related protein 2, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
- Molecular Weight
- 33.6 kDa
- UniProt
- Q9ES89
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