FAM171B Protein (His tag)

Catalog No. ABIN7195640

Recombinant FAM171B protein expressed in HEK-293 Cells.

Quick Overview for FAM171B Protein (His tag) (ABIN7195640)

Target: FAM171B (Family with Sequence Similarity 171, Member B (FAM171B))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 90 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This FAM171B protein is labelled with His tag.

Purpose: Recombinant Human FAM171B/KIAA1946 Protein (His Tag)

Sequence: Met 1-Thr355

Characteristics: A DNA sequence encoding the human FAM171B (AAH60872.1) (Met1-Thr355) was expressed with a C-terminal polyhistidine tag.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: FAM171B (Family with Sequence Similarity 171, Member B (FAM171B))

Alternative Name: FAM171B/KIAA1946

Background:

Background: RAMP3 belongs to the RAMP family. Members of this family are single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs have a wide biological distribution, high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels present in the testes, gastrointestinal tract and thyroid. RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. They are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of RAMP3 protein, CRLR functions as an adrenomedullin receptor.

Synonym: KIAA1946

Molecular Weight: 37.5 kDa