FABP4 Protein (MYC tag,His tag)

Catalog No. ABIN7195658

Product Details

Target: FABP4 (Fatty Acid Binding Protein 4, Adipocyte (FABP4))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This FABP4 protein is labelled with MYC tag,His tag.

Purpose: Recombinant Mouse FABP4/A-FABP Protein (His & MYC Tag)

Sequence: Cys2-Ala132

Characteristics: A DNA sequence encoding the mouse Fabp4 (NP_077717.1) (Cys2-Ala132) was expressed with a polyhistidine tag at the N-terminus and a myc tag at the C-terminus.

Purity: > 95 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 20 % glycerol, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: FABP4 (Fatty Acid Binding Protein 4, Adipocyte (FABP4))

Alternative Name: FABP4/A-FABP (FABP4 Products)

Synonyms: A-FABP Protein, AFABP Protein, ALBP Protein, aP2 Protein, LOC100223994 Protein, FABP Protein, AP2 Protein, FABP3 Protein, FABP4 Protein, MGC84940 Protein, fabp4 Protein, 422/aP2 Protein, ALBP/Ap2 Protein, Ap2 Protein, Lbpl Protein, Albp Protein, fatty acid binding protein 4 Protein, fatty acid-binding protein, adipocyte Protein, fatty acid binding protein 4, adipocyte Protein, fatty acid binding protein 4, adipocyte L homeolog Protein, Fatty acid-binding protein, adipocyte Protein, adipocyte fatty acid-binding protein Protein, adipocyte fatty acid binding protein Protein, FABP4 Protein, LOC100223994 Protein, fabp4.L Protein, fabp4 Protein, Fabp4 Protein, LOC100732353 Protein, LOC100861279 Protein, LOC100057425 Protein, LOC395224 Protein

Background:

Background: Fatty acid-binding protein, adipocyte, also known as Adipocyte-type fatty acid-binding protein, Fatty acid-binding protein 4, Adipocyte lipid-binding protein, and FABP4, is a cytoplasm protein which belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. In familial combined hyperlipidemia (FCHL), FABP4 correlated to body mass index (BMI), waist circumference and homeostasis model assessment (HOMA) index.FABP4 levels were associated with triglyceride-rich lipoproteins. In humans serum FABP4 levels correlate significantly with features of PCOS. It appears to be a determinant of atherogenic dyslipidemia. FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte-specific Pten-null mice. FABP4 concentration significantly increased with an increasing of MS features and was strongly correlated with body-mass index, triglycerides, HDL-cholesterol concentrations and blood pressure. Patients in the highest quartile of FABP4 presented a six-fold increased odds ratio for MS and a three-fold increased odds for LD, adjusted by age, sex, body-mass index and the antiretroviral therapy. FABP4 is a strong plasma marker of metabolic disturbances in HIV-infected patients, and therefore, could serve to guide therapeutic intervention in this group of patients.

Synonym: 422/aP2;ALBP/Ap2;Ap2;Lbpl

Molecular Weight: 16.5 kDa

NCBI Accession: NP_077717

Pathways: Brown Fat Cell Differentiation