FTL Protein (His tag)

Catalog No. ABIN7319279

Product Details

Target: FTL (Ferritin, Light Polypeptide (FTL))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This FTL protein is labelled with His tag.

Purpose: Recombinant Human FTL Protein (His Tag)

Sequence: Met 1-Asp175

Characteristics: Recombinant Human Ferritin light chain is produced by our E.coli expression system and the target gene encoding Met1-Asp175 is expressed with a 6His tag at the N-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM Tris,250 mM NaCl,1 mM EDTA, pH 9.5.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: FTL (Ferritin, Light Polypeptide (FTL))

Alternative Name: FTL (FTL Products)

Synonyms: NBIA3 Protein, apoferritin Protein, ferritin Protein, fhc Protein, fth Protein, fth1 Protein, fthl6 Protein, ftn-2 Protein, pig15 Protein, plif Protein, FT Protein, Ftl Protein, Ftl-1 Protein, L-ferritin Protein, FTL Protein, Ftl1 Protein, FTL2 Protein, FTD Protein, ferritin light chain Protein, ferritin, heavy polypeptide 1 L homeolog Protein, ferritin light polypeptide 1 Protein, ferritin, light polypeptide Protein, ferritin light-chain Protein, ferritin light chain 1 Protein, FTL Protein, fth1.L Protein, Ftl1 Protein, CpipJ_CPIJ004069 Protein, Ftl Protein

Background:

Background: Ferritin is a large, iron-storage heteropolymeric protein,which is expressed in most kinds of cells and co-assemble in different proportion in a tissue-specific manner. Ferritin has oligomer of 24 subunits and two types of subunits including light chain(FTL) and heavy chain. Ferritin can remove Fe (II) from solution in the presence of oxygen and is very important for iron homeostasis. Iron is absorbed in the ferrous form and deposited as ferric hydroxides after oxidation. Iron is first oxidized to the ferric state for storage as ferric oxyhdroxide whithin the protein shell of ferritin. Thus, ferritin removes excess iron from the cell sap where it could otherwise participate in peroxidation mechanisms. Ferritin also plays a role in delivery of iron to cells and mediates iron uptake in capsule cells of the developing kidney.

Synonym: Ferritin L subunit,Ferritin light chain, FTL

Molecular Weight: 24.5 kDa

UniProt: P02792

Pathways: Transition Metal Ion Homeostasis