FGL1 Protein (His tag)
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- Target See all FGL1 Proteins
- FGL1 (Fibrinogen-Like 1 (FGL1))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Cynomolgus
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Source
- Human Cells
- Purification tag / Conjugate
- This FGL1 protein is labelled with His tag.
- Purpose
- Recombinant Cynomolgus FGL1 (C-6His)
- Sequence
- Leu23-Ile312
- Characteristics
- Recombinant Cynomolgus Fibrinogen-like Protein 1 is produced by our Mammalian expression system and the target gene encoding Leu23-Ile312 is expressed with a 6His tag at the C-terminus.
- Purity
- >95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Loaded Cynomolgus LAG-3-Fc(Cat#PKSQ050015) on Protein A Biosensor, can bind Cynomolgus FGL1-His(Cat#PKSQ050095) with an affinity constant of 28.6nM as determined in BLI assay.
- Top Product
- Discover our top product FGL1 Protein
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 300 mM NaCl, 10 % Glycerol, 2 mM EDTA, pH 8.0.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- FGL1 (Fibrinogen-Like 1 (FGL1))
- Alternative Name
- FGL1 (FGL1 Products)
- Synonyms
- MGC84748 Protein, FGL1 Protein, DKFZp470A2333 Protein, Frep1 Protein, Lfire1 Protein, HFREP1 Protein, HP-041 Protein, LFIRE-1 Protein, LFIRE1 Protein, Mfire1 Protein, fibrinogen like 1 L homeolog Protein, fibrinogen like 1 Protein, fibrinogen-like 1 Protein, fibrinogen-like protein 1 Protein, fgl1.L Protein, FGL1 Protein, Fgl1 Protein
- Background
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Background: Hepassocin, also known as hepatocyte-derived fibrinogen-related protein 1 (HFREP-1), is a liver-specific secreted protein belonging to the fibronogen superfamily, whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3 .
Synonym: Angiopoietin-related protein 4, 425O18-1, Angiopoietin-like protein 4, Fasting-induced adipose factor, Hepatic fibrinogen/angiopoietin-related protein, HFARP, Secreted protein Bk89, Angptl4, Farp, Fiaf, Ng27
- Molecular Weight
- 34.8 kDa
- UniProt
- A0A2K5X990
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