FUT10 Protein (His tag)

Catalog No. ABIN7317576

Product Details

Target: FUT10 (Fucosyltransferase 10 (Alpha (1,3) Fucosyltransferase) (FUT10))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This FUT10 protein is labelled with His tag.

Purpose: Recombinant Human FUT10/Fucosyltransferase 10 Protein (His Tag)

Sequence: Leu 32-Asp 479

Characteristics: A DNA sequence encoding the lumenal domain of human FUT10 (Q6P4F1-1) (Leu 32-Asp 479) was expressed, with a polyhistidine tag at the N-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: FUT10 (Fucosyltransferase 10 (Alpha (1,3) Fucosyltransferase) (FUT10))

Alternative Name: FUT10/Fucosyltransferase 10 (FUT10 Products)

Synonyms: FUT10 Protein, fut10A Protein, zgc:195147 Protein, fucosyltransferase 10 Protein, fucosyltransferase 10 (alpha (1,3) fucosyltransferase) L homeolog Protein, FUT10 Protein, Fut10 Protein, fut10 Protein, fut10.L Protein

Background:

Background: EPH receptor A4 (ephrin type-A receptor 4), also known as EphA4, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. EphA4 is enriched on dendritic spines of pyramidal neurons in the adult mouse hippocampus, and ephrin-A3 is localized on astrocytic processes that envelop spines. Eph receptor−mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). The extracellular domain of an EphA4 interacts with ephrin ligands, which may be tethered to neighbouring cells. Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer.

Synonym: FUT10;MGC11141

Molecular Weight: 54.7 kDa