GLIPR1 Protein (His tag)
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- Target See all GLIPR1 Proteins
- GLIPR1 (GLI Pathogenesis-Related 1 (GLIPR1))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This GLIPR1 protein is labelled with His tag.
- Purpose
- Recombinant Mouse GLIPR1 Protein (His Tag)
- Sequence
- Met1-Thr223
- Characteristics
- A DNA sequence encoding the mouse GLIPR1 (NP_082884.1) (Met1-Thr223) was expressed with a C-terminal polyhistidine tag.
- Purity
- > 85 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product GLIPR1 Protein
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GLI Pathogenesis-Related 1 (GLIPR1) (AA 23-99) protein (GST tag)
GLIPR1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
GLI Pathogenesis-Related 1 (GLIPR1) (AA 22-266) protein (rho-1D4 tag)Crystallography grade GLIPR1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
GLI Pathogenesis-Related 1 (GLIPR1) (AA 18-255) protein (rho-1D4 tag)Crystallography grade GLIPR1 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- GLIPR1 (GLI Pathogenesis-Related 1 (GLIPR1))
- Alternative Name
- GLIPR1 (GLIPR1 Products)
- Synonyms
- CRISP7 Protein, GLIPR Protein, RTVP1 Protein, 2410114O14Rik Protein, RTVP-1 Protein, mRTVP-1 Protein, GLIPR1 Protein, zgc:65887 Protein, GLI pathogenesis related 1 Protein, GLI pathogenesis-related 1 Protein, GLI pathogenesis-related 1 (glioma) Protein, GLI pathogenesis-related 1b Protein, GLIPR1 Protein, Glipr1 Protein, glipr1b Protein
- Background
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Background: Glioma pathogenesis-related protein 1, also known as Protein RTVP-1, GLIPR1 and GLIPR, is a single-pass membrane protein which belongs to the CRISP family. GLIPR1 / RTVP-1 was expressed in high levels in glioblastomas, whereas its expression in low-grade astrocytomas and normal brains was very low. Transfection of glioma cells with small interfering RNAs targeting GLIPR1 / RTVP-1 decreased cell proliferation in all the cell lines examined and induced cell apoptosis in some of them. Overexpression of GLIPR1 / RTVP-1 increased astrocyte and glioma cell proliferation and the anchorage-independent growth of the cells. In addition, overexpression of GLIPR1 / RTVP-1 rendered glioma cells more resistant to the apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand and serum deprivation. GLIPR1 / RTVP-1 regulated the invasion of glioma cells was evident by their enhanced migration through Matrigel and by their increased invasion in a spheroid confrontation assay. The increased invasive potential of the GLIPR1 / RTVP-1 overexpressors was also shown by the increased activity of matrix metalloproteinase 2 in these cells. The expression of GLIPR1 / RTVP-1 is correlated with the degree of malignancy of astrocytic tumors and that GLIPR1 / RTVP-1 is involved in the regulation of the growth, survival, and invasion of glioma cells. GLIPR1 / RTVP-1 is a potential therapeutic target in gliomas.
Synonym: 2410114O14Rik;mRTVP-1;RTVP-1;RTVP1
- Molecular Weight
- 25.1 kDa
- NCBI Accession
- NP_082884
- Pathways
- Regulation of Lipid Metabolism by PPARalpha
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