GSTM2 Protein (GST tag,His tag)

Catalog No. ABIN7317428

Product Details

Target: GSTM2 (Glutathione S-Transferase mu 2 (Muscle) (GSTM2))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This GSTM2 protein is labelled with GST tag,His tag.

Purpose: Recombinant Human GSTM2/GST4 Protein (His Tag)

Sequence: Met 1-Lys 218

Characteristics: A DNA sequence encoding the native human GSTM2 (P28161) (Met 1-Lys 218) was expressed, with a polyhistide tag at the N-terminus.

Purity: > 97 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 150 mM NaCl, 10 mM CaCl2, 0.05 % Brig-35, pH 7.5

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: GSTM2 (Glutathione S-Transferase mu 2 (Muscle) (GSTM2))

Alternative Name: GSTM2/GST4 (GSTM2 Products)

Synonyms: GSTA4 Protein, GST4 Protein, GSTM Protein, GSTM2-2 Protein, GTHMUS Protein, Gstb-2 Protein, Gstb2 Protein, GSTIV Protein, glutathione S-transferase mu 2 Protein, glutathione S-transferase mu 2 (muscle) Protein, glutathione S-transferase Mu 2 Protein, glutathione S-transferase, mu 2 Protein, glutathione S-transferase 2 Protein, Glutathione S-transferase 4 Protein, Gstm2 Protein, GSTM2 Protein, LOC100732167 Protein, gst2 Protein, gst-4 Protein

Background:

Background: Glutathione S-transferase Mu 2, also known as GST class-mu 2, GSTM2-2 and GSTM2, is a cytoplasm protein which belongs to the GST superfamily and Mu family. GSTM2 / GST4 contains one GST C-terminal domain and one GST N-terminal domain. The glutathione S-transferases (GSTs) are a multigene family of enzymes largely involved in the detoxification of chemicals. Eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. Butyrate, an important luminal component produced from fermentation of dietary fibers, is an efficient inducer of GSTs and especially of GSTM2. Butyrate may act chemoprotectively by increasing detoxification capabilities in the colon mucosa.

Synonym: GST4;GSTM;GSTM2-2;GTHMUS

Molecular Weight: 27.2 kDa

UniProt: P28161

Pathways: Negative Regulation of Transporter Activity