IL-11 Protein (AA 23-199)

Catalog No. ABIN7319568

This Recombinant IL-11 protein is expressed in Yeast (Pichia pastoris).

Quick Overview for IL-11 Protein (AA 23-199) (ABIN7319568)

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Protein Type: Recombinant

Origin: Human

Source: Yeast (Pichia pastoris)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 23-199

Purpose: Recombinant Human Interleukin-11/IL-11 Protein

Sequence: Gly23-Leu199

Characteristics: Recombinant Human Interleukin-11 is produced by our Yeast expression system and the target gene encoding Gly23-Leu199 is expressed.

Sterility: 0.2 μm filtered

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 2 % Glycine, pH 7.2.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Alternative Name: Interleukin-11/IL-11

Background: Interleukin,Adipogenesis Inhibitory Factor,AGIF,AGIF (Adipogenesis Inhibitory Factor),IL-11,Interleukin-11,Oprelvekin,IL11,Interleukin 11 (IL-11) is a member of a family of human growth factors that includes human growth hormone, granulocyte colony-stimulating factor, and other growth factors. IL-11 is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. It also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2, It activates a signaling cascade that promotes cell proliferation. The signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.

Molecular Weight:

Calculated MW: 19.0 kDa

Observed MW: 19 kDa

Gene ID: 3589

UniProt: P20809

Pathways: JAK-STAT Signaling, Negative Regulation of Hormone Secretion