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IL-11 Protein

This Recombinant IL-11 protein is expressed in Yeast (Pichia pastoris).
Catalog No. ABIN7319568

Quick Overview for IL-11 Protein (ABIN7319568)

Target

See all IL-11 (IL11) Proteins
IL-11 (IL11) (Interleukin 11 (IL11))

Protein Type

Recombinant

Origin

  • 15
  • 10
  • 2
  • 2
Human

Source

  • 15
  • 6
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Yeast (Pichia pastoris)

Purity

> 95 % as determined by reducing SDS-PAGE.
  • Purpose

    Recombinant Human Interleukin-11/IL-11 Protein

    Sequence

    Gly23-Leu199

    Characteristics

    Recombinant Human Interleukin-11 is produced by our Yeast expression system and the target gene encoding Gly23-Leu199 is expressed.

    Endotoxin Level

    < 1.0 EU per μg as determined by the LAL method.
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  • Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Please refer to the printed manual for detailed information.

    Buffer

    Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 2 % Glycine, pH 7.2.

    Storage

    4 °C,-20 °C,-80 °C

    Storage Comment

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target

    IL-11 (IL11) (Interleukin 11 (IL11))

    Alternative Name

    Interleukin-11/IL-11

    Background

    Background: Interleukin 11 (IL-11) is a member of a family of human growth factors that includes human growth hormone, granulocyte colony-stimulating factor, and other growth factors. IL-11 is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. It also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2, It activates a signaling cascade that promotes cell proliferation. The signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.

    Synonym: Interleukin-11, IL-11, Adipogenesis Inhibitory Factor, AGIF, Oprelvekin, IL11

    Molecular Weight

    19 kDa

    UniProt

    P20809

    Pathways

    JAK-STAT Signaling, Negative Regulation of Hormone Secretion
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