IL18R1 Protein (His tag,Fc Tag)

Catalog No. ABIN7196449

Product Details

Target: IL18R1 (Interleukin 18 Receptor 1 (IL18R1))

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This IL18R1 protein is labelled with His tag,Fc Tag.

Purpose: Recombinant Mouse IL18R1/CD218a Protein (His & Fc Tag)(Active)

Sequence: Met 1-Gly 326

Characteristics: A DNA sequence encoding the extracellular domain (Met 1-Gly 326) of mouse IL18R1 (NP_032391.1) precursor was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Purity: > 98 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to bind Cynomolgus IL-18 in a functional ELISA.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: IL18R1 (Interleukin 18 Receptor 1 (IL18R1))

Alternative Name: IL18R1/CD218a (IL18R1 Products)

Synonyms: CD218a Protein, CDw218a Protein, IL-1Rrp Protein, IL18RA Protein, IL1RRP Protein, IL-1R9 Protein, IL1R9 Protein, IL1RAPL-2 Protein, TIGIRR-1 Protein, Il18ralpha Protein, Il1rrp Protein, IL-18Ra Protein, IL18R1 Protein, interleukin 18 receptor 1 Protein, interleukin 1 receptor accessory protein like 2 Protein, IL18R1 Protein, IL1RAPL2 Protein, Il18r1 Protein

Background:

Background: Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. This receptor is specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.

Synonym: Il18ralpha,Il1rrp

Molecular Weight: 63.5 kDa

NCBI Accession: NP_032391