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Latexin Protein (LXN) (Fc Tag)

LXN Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7196735
  • Target See all Latexin (LXN) Proteins
    Latexin (LXN)
    Protein Type
    Recombinant
    Origin
    • 5
    • 3
    • 3
    Human
    Source
    • 7
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Latexin protein is labelled with Fc Tag.
    Purpose
    Recombinant Human Latexin/LXN Protein (Fc Tag)
    Sequence
    Glu 2-Glu 222
    Characteristics
    A DNA sequence encoding the human Latexin (NP_064554.3) (Glu 2-Glu 222) was fused with the Fc region of human IgG1 at the N-terminus.
    Purity
    > 90 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product LXN Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 100 mM Glycine, 10 mM NaCl, 50 mM Tris, pH 7.5
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    Latexin (LXN)
    Alternative Name
    Latexin/LXN (LXN Products)
    Synonyms
    wu:fk66c02 Protein, zgc:103612 Protein, LXN Protein, lxn Protein, ECI Protein, TCI Protein, latexin Protein, lxn Protein, LXN Protein, Lxn Protein
    Background

    Background: Latexin; also known as endogenous carboxypeptidase inhibitor; tissue carboxypeptidase inhibitor; TCI; ECI and LXN; is a cytoplasm protein which belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in heart; prostate; ovary; kidney; pancreas; and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart; prostate; ovary; kidney; pancreas; and colon; but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets; and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors; Latexin is related to a human putative tumor suppressor protein; TIG1. In addition; Latexin is also implicated in Alzheimer's disease.

    Synonym: ECI;TCI

    Molecular Weight
    52 kDa
    NCBI Accession
    NP_064554
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