MESDC2 Protein (His tag)

Catalog No. ABIN7317713

Product Details

Target: MESDC2 (Mesoderm Development Candidate 2 (MESDC2))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This MESDC2 protein is labelled with His tag.

Purpose: Recombinant Human MESDC2/MESD Protein (His Tag)

Sequence: Ala 34-Lys 230

Characteristics: A DNA sequence encoding the human MESDC2 (NP_055969.1) (Ala 34-Lys 230) was fused with a signal peptide at the N-terminus and a polyhistidine tag at the C-terminus.

Purity: > 97 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: MESDC2 (Mesoderm Development Candidate 2 (MESDC2))

Alternative Name: MESDC2/MESD (MESDC2 Products)

Synonyms: MGC115616 Protein, MESDC2 Protein, BOCA Protein, MESD Protein, 2210015O11Rik Protein, AW537813 Protein, mKIAA0081 Protein, mesd Protein, msd Protein, zgc:158636 Protein, mesoderm development LRP chaperone Protein, mesoderm development LRP chaperone L homeolog Protein, mesoderm development candidate 2 Protein, MESD Protein, mesd.L Protein, CpipJ_CPIJ010816 Protein, Tsp_04045 Protein, mesd Protein, Mesd Protein, MESDC2 Protein

Background:

Background: LDLR chaperone MESD, also known as Mesoderm development protein, Mesoderm development candidate 2, Renal carcinoma antigen NY-REN-61 and MESDC2, is a member of the MESD family. MESDC2 is a chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). The LDLR maturation activity resides in the N- and C-terminal unstructured regions. MESDC2 acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway. MESDC2 is essential for specification of embryonic polarity and mesoderm induction.

Synonym: BOCA,MESD

Molecular Weight: 23.6 kDa

NCBI Accession: NP_055969