Merlin Protein (His tag)
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- Target See all Merlin (NF2) Proteins
- Merlin (NF2) (Neurofibromin 2 (NF2))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Merlin protein is labelled with His tag.
- Purpose
- Recombinant Human Merlin/NF2 protein (His Tag)
- Sequence
- 1M-595L
- Characteristics
- A DNA sequence encoding the Human Merlin/NF2 (P35240-1) (1M-595L) was expressed with a polyhistidine tag at the N-terminus.
- Purity
- >90 % as determined by reducing SDS-PAGE.
- Biological Activity Comment
- Immunogen(E-AB-40336)
- Top Product
- Discover our top product NF2 Protein
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Neurofibromin 2 (NF2) (AA 1-82) protein (GST tag)
NF2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Neurofibromin 2 (NF2) (AA 1-596) protein (Strep Tag)Crystallography grade NF2 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Neurofibromin 2 (NF2) proteinNF2 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % WB, SDS, ELISA, IP
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as sterile Tris,EDTA,PH 8.0.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Samples are stable for up to twelve months from date of receipt at -70°C.Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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- Target
- Merlin (NF2) (Neurofibromin 2 (NF2))
- Alternative Name
- Merlin/NF2 (NF2 Products)
- Synonyms
- ACN Protein, BANF Protein, SCH Protein, NF2 Protein, merlin Protein, zgc:194620 Protein, zgc:194631 Protein, NF2a Protein, nf2 Protein, neurofibromin 2 Protein, neurofibromin 2a (merlin) Protein, neurofibromin 2b (merlin) Protein, neurofibromin 2 (merlin) S homeolog Protein, NF2 Protein, Nf2 Protein, nf2a Protein, nf2b Protein, nf2.S Protein
- Background
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Background: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
Synonym: CAN, BANF, Bilateral acoustic neuroma, MERL_HUMAN, Merlin, Moesin ezrin radixin like protein, Moesin ezrin radizin like, Moesin-ezrin-radixin-like, Neurofibromatosis 2, Neurofibromatosis type 2, Neurofibromatosis2, NF 2, SCH, Schwannomerlin
- Molecular Weight
- 69.7kDa
- Pathways
- Cell-Cell Junction Organization
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