PARM1 Protein (His tag)
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- Target See all PARM1 Proteins
- PARM1 (Prostate Androgen-Regulated Mucin-Like Protein 1 (PARM1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This PARM1 protein is labelled with His tag.
- Purpose
- Recombinant Human PARM1/PARM-1 Protein (His Tag)
- Sequence
- Met 1-Ser258
- Characteristics
- A DNA sequence encoding the human PARM1 (AAH13294.1) (Met1-Ser258) was expressed with a polyhistidine tag at the C-terminus.
- Purity
- > 85 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product PARM1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- PARM1 (Prostate Androgen-Regulated Mucin-Like Protein 1 (PARM1))
- Alternative Name
- PARM1/PARM-1 (PARM1 Products)
- Synonyms
- DKFZP564O0823 Protein, DKFZp564O0823 Protein, PARM-1 Protein, 2210012L08Rik Protein, 9130213B05Rik Protein, W91666 Protein, Cipar1 Protein, WSC4 Protein, CIPAR-1 Protein, prostate androgen-regulated mucin-like protein 1 Protein, PARM1 Protein, Parm1 Protein
- Background
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Background: Calsequestrin-1 is an isoform of calsequestrin. Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. It helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. Two forms of calsequestrin have been identified: Calsequestrin-2 and Calsequestrin-1. Calsequestrin-1 is found in fast skeletal muscle. The release of calsequestrin-bound calcium (through a calcium release channel) triggers muscle contraction. The active protein is not highly structured, more than 50 % of it adopting a random coil conformation. When calcium binds there is a structural change whereby the alpha-helical content of the protein increases from 3 to 11 %. Both forms of calsequestrin are phosphorylated by casein kinase 2, but the cardiac form is phosphorylated more rapidly and to a higher degree. Calsequestrin-1 is also secreted in the gut where it deprives bacteria of calcium ions.
Synonym: Cipar1,DKFZP564O0823,PARM-1,WSC4
- Molecular Weight
- 25.7 kDa
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