PPM1G Protein (AA 317-546) (His tag)

Catalog No. ABIN7317604

Product Details

Target: PPM1G (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G))

Protein Type: Recombinant

Protein Characteristics: AA 317-546

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This PPM1G protein is labelled with His tag.

Purpose: Recombinant Human PPM1G/PP2C-gamma Protein (aa 317-546, His Tag)

Sequence: Met 317-Asp 546

Characteristics: A DNA sequence encoding the human PPM1G (O15355) C-terminal fragment (Met 317-Asp 546) was expressed, with a polyhistidine tag at the N-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 1 mM DTT, 20 % glycerol, pH 7.5

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: PPM1G (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G))

Alternative Name: PPM1G/PP2C-gamma (PPM1G Products)

Synonyms: AI385652 Protein, Fin13 Protein, PP2CG Protein, PP2CGAMMA Protein, PPP2CG Protein, protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform Protein, protein phosphatase, Mg2+/Mn2+ dependent 1G Protein, protein phosphatase, Mg2+/Mn2+ dependent, 1G Protein, Ppm1g Protein, PPM1G Protein

Background:

Background: Protein phosphatase 1G; also known as Protein phosphatase 1C; Protein phosphatase 2C isoform gamma; Protein phosphatase magnesium-dependent 1 gamma; PP2C-gamma; PPM1G and PPM1C; is a cytoplasm protein which belongs to the PP2C family. PPM1G / PP2C-gamma is widely expressed. It is most abundant in testis; skeletal muscle; and heart. Alternatively spliced transcript variants encoding the same protein have been described. PP2C family members are known to be negative regulators of cell stress response pathways.  PPM1G / PP2C-gamma is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors; which is important for the formation of functional spliceosome. PPM1G / PP2C-gamma also plays a role in regulating cell cycle progression.

Synonym: Protein Phosphatase 1G; Protein Phosphatase 1C; Protein Phosphatase 2C Isoform Gamma; PP2C-Gamma; Protein Phosphatase Magnesium-Dependent 1 Gamma; PPM1G; PP2CG;PP2CGAMMA

Molecular Weight: 26.6 kDa

UniProt: O15355