PTPRN Protein (AA 576-950) (His tag)
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- Target See all PTPRN Proteins
- PTPRN (Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 576-950
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This PTPRN protein is labelled with His tag.
- Purpose
- Recombinant Human IA2/PTPRN Protein (aa 576-950, His Tag)
- Sequence
- Arg576-Gln950
- Characteristics
- Recombinant Human Islet Cell Antigen 2/Protein Tyrosine Phosphatase Receptor-type N is produced by our E.coli expression system and the target gene encoding Arg576-Gln950 is expressed with a 6His tag at the N-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product PTPRN Protein
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Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) (AA 693-979) protein (His tag)
PTPRN Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) (AA 107-332) protein (His tag)PTPRN Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) (AA 205-311) protein (GST tag)PTPRN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) (AA 601-979) protein (His tag)Crystallography grade PTPRN Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) (AA 601-979) protein (His tag)Crystallography grade PTPRN Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) (AA 35-575) protein (His tag)Crystallography grade PTPRN Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) (AA 38-575) protein (His tag)Crystallography grade PTPRN Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) (AA 35-979) protein (rho-1D4 tag)Crystallography grade PTPRN Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) (AA 38-979) protein (rho-1D4 tag)Crystallography grade PTPRN Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl, pH 8.0.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- PTPRN (Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN))
- Alternative Name
- IA2/PTPRN (PTPRN Products)
- Synonyms
- IA-2 Protein, IA-2/PTP Protein, IA2 Protein, ICA512 Protein, R-PTP-N Protein, mIA-A Protein, mKIAA4064 Protein, Ia-2 Protein, fc43c04 Protein, ptprn Protein, wu:fc43c04 Protein, ia-2 Protein, ia2 Protein, ica512 Protein, r-ptp-n Protein, protein tyrosine phosphatase, receptor type N Protein, protein tyrosine phosphatase, receptor type, N Protein, protein tyrosine phosphatase, receptor type, Na Protein, protein tyrosine phosphatase, receptor type N L homeolog Protein, PTPRN Protein, Ptprn Protein, ptprna Protein, ptprn.L Protein
- Background
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Background: Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity, may play a role in the regulation of secretory granules via its interaction with SNTB2. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.
Synonym: Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512
- Molecular Weight
- 44.6 kDa
- UniProt
- Q16849
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