PTMA Protein (GST tag)

Catalog No. ABIN7317565

Product Details

Target: PTMA (Prothymosin, alpha (PTMA))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This PTMA protein is labelled with GST tag.

Purpose: Recombinant Human PTMA Protein (GST Tag)

Sequence: Ser 2-Asp 111

Characteristics: A DNA sequence encoding the human PTMA (P06454-1) (Ser 2-Asp 111) was fused with the GST tag at the N-terminus.

Purity: > 90 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.5

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: PTMA (Prothymosin, alpha (PTMA))

Alternative Name: PTMA (PTMA Products)

Synonyms: TMSA Protein, ptma Protein, MGC64300 Protein, tmsa Protein, Thym Protein, ptma-a Protein, ptma-b Protein, prothymosin, alpha Protein, prothymosin, alpha L homeolog Protein, prothymosin alpha Protein, prothymosin, alpha S homeolog Protein, PTMA Protein, ptma.L Protein, ptma Protein, Ptma Protein, ptma.S Protein

Background:

Background: PTMA (prothymosin, alpha, N-GST chimera) is a small, 12.4 kDa protein. It is a 109-111 amino acid long polypeptide as the precursor of thymosin a1. Thymosins are named becaues they were originally isolated from the thymus. But now in many other tissues, thymosins also can be detected. Thymosins have diverse biological activities, and two in particular, thymosins a1 and _4, have potentially important uses in medicine, some of which have already progressed from the laboratory to the clinic. In general, PTMA is associated with cellular proliferation and carcinogenesis (Eschenfeldt et al., 1986), cellular and viral transcription (Cotter et al., 2000), protection against apoptosis and chromatin remodelling (Karetsou et al., 1998). PTMA may have a dual role both intracellulary and extracellulary. In relation to diseases, thymosins have been categorized as biological response modifiers. Thymosin a1 is derived from PTMA. For animals that lack thymus glands, thymosin a1 is responsible for the activity of that preparation in restoring immune function.

Synonym: TMSA

Molecular Weight: 39 kDa