PDK4 Protein (AA 1-412) (His-GST)
Quick Overview for PDK4 Protein (AA 1-412) (His-GST) (ABIN7320000)
Target
See all PDK4 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 1-412
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Purification tag / Conjugate
- This PDK4 protein is labelled with His-GST.
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Purpose
- Recombinant Mouse PDK4 Protein (His & GST Tag)
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Sequence
- Met1-Val412
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Characteristics
- A DNA sequence encoding the mouse PDK4 (O70571) (Met1-Val412) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Kinase activity untested
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Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) (AA 1-411) protein (GST tag)
PDK4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) (AA 138-368) protein (His-IF2DI Tag)PDK4 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) protein (Myc-DYKDDDDK Tag)PDK4 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) proteinPDK4 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % WB, SDS, ELISA, IP
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Expiry Date
- 6 months
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- PDK4 (Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))
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Alternative Name
- PDK4
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Background
- AV005916,Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial protein that regulates the TCA cycle.PDK4, a vital mitochondrial protein, controls the switch between glycolysis and oxidative phosphorylation based upon nutrient availability.Pyruvate dehydrogenase kinase 4 (PDK4) mRNA has been reported as an up-regulated gene in the heart and skeletal muscle of carnitine-deficient juvenile visceral steatosis (JVS) mice under fed conditions. PDK4 plays an important role in the inhibition of glucose oxidation via the phosphorylation of pyruvate dehydrogenase complex (PDC).PDK4 gene expression is stimulated by thyroid hormone (T(3)), glucocorticoids, and long chain fatty acids.
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Molecular Weight
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Calculated MW: 74.4 kDa
Observed MW: 65 kDa
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UniProt
- O70571
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Pathways
- PI3K-Akt Signaling, Hedgehog Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect
Target
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