REG1B Protein (His tag)

Catalog No. ABIN7317513

Product Details

Target: REG1B (Regenerating Islet-Derived 1 beta (REG1B))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This REG1B protein is labelled with His tag.

Purpose: Recombinant Human REG1B/PSPS2 Protein (His Tag)

Sequence: Met 1-Asn 166

Characteristics: A DNA sequence encoding the human REG1B (NP_006498.1) (Met 1-Asn 166) was fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: REG1B (Regenerating Islet-Derived 1 beta (REG1B))

Alternative Name: REG1B/PSPS2 (REG1B Products)

Synonyms: PSPS2 Protein, REGH Protein, REGI-BETA Protein, REGL Protein, regenerating family member 1 beta Protein, REG1B Protein

Background:

Background: Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory protein with a growth stimulating effect on pancreatic beta cells, and could be associated with fibrocalculous pancreatopathy. Reg and Reg-related genes which were expressed in various organs have been revealed to constitute a multigene family, the Reg family consisting of four subtypes (types I, II, III, IV) and are involved in cancers and neurodegenerative diseases. Regenerating islet-derived 1 beta (REG1B), also known as Lithostathine-1-beta and Pancreatic stone protein 2 (PSPS2), is a types I Reg protein and contains one typical C-type lectin domain. REG1B is a 166-amino acid protein which has 22 amino acid substitutions in comparison with the previously isolated human REG1A, and it is was expressed only in pancreas. REG1B Is normally found in the exocrine pancreas, whereas in other tissues it appears either only under pathological conditions, such as Alzheimer's disease (brain), cancer (colon), or during regeneration such as neuronal sprouting in brain and pancreas regeneration. REG1B might act as an inhibitor of spontaneous calcium carbonate precipitation. The REG1A and REG1B gene and proteins could play different roles in the pancreas.

Synonym: PSPS2,REGH,REGI-BETA,REGL

Molecular Weight: 17.7 kDa

NCBI Accession: NP_006498