S100A2 Protein (Fc Tag)

Catalog No. ABIN7317982

Product Details

Target: S100A2 (S100 Calcium Binding Protein A2 (S100A2))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This S100A2 protein is labelled with Fc Tag.

Purpose: Recombinant Human S100A2 Protein (Fc Tag)

Sequence: Met 2-Pro98

Characteristics: A DNA sequence encoding the human S100A2 (NP_005969.1) (Met 2-Pro98) was expressed with the fused Fc region of human IgG1 at the N-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 100 mM Glycine, 10 mM NaCl, 50 mM Tris, pH 7.5

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: S100A2 (S100 Calcium Binding Protein A2 (S100A2))

Alternative Name: S100A2 (S100A2 Products)

Synonyms: S100A2 Protein, CAN19 Protein, S100L Protein, CaN19 Protein, EG628324 Protein, S100 calcium binding protein A2 Protein, S100A2 Protein, S100a2 Protein

Background:

Background: The calcium-binding Protein S100A2 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 family genes are located as a cluster on chromosome 1q21, and S100 proteins consisting of at least 20 members are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. S100A2 was first detected in lung and kidney, and is mainly expressed in a subset of tissues and cells such as breast epithelia and liver. The S100A2 protein is a homodimer that undergoes a conformational change upon binding of calcium, and the active form functions in regulating cell proliferation and differentiation, gene transcription, and p53-dependent growth arrest and apoptosis. Accordingly, this protein is regarded as a putative tumor suppressor, and thus chromosomal rearrangements and reduced expression of S100A2 gene have been implicated in certain carcinomas.

Synonym: Protein S100-A2, CAN19, Protein S-100L, S100 calcium-binding protein A2, S100A2, S100L

Molecular Weight: 37.6 kDa

NCBI Accession: NP_005969

Pathways: S100 Proteins