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S100A3 Protein (His tag,MBP tag)

S100A3 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7317649
  • Target See all S100A3 Proteins
    S100A3 (S100 Calcium Binding Protein A3 (S100A3))
    Protein Type
    Recombinant
    Origin
    • 5
    • 3
    • 2
    Human
    Source
    • 5
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This S100A3 protein is labelled with His tag,MBP tag.
    Purpose
    Recombinant Human S100A3/S100E Protein (His & MBP Tag)
    Sequence
    Met 1-Gln 101
    Characteristics
    A DNA sequence encoding the human S100A3 (P33764) (Met 1-Gln 101) was fused with an N-terminal polyhistidine-tagged MBP tag at the N-terminus.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product S100A3 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, 20 % glycerol, pH 7.4
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    S100A3 (S100 Calcium Binding Protein A3 (S100A3))
    Alternative Name
    S100A3/S100E (S100A3 Products)
    Synonyms
    S100E Protein, S100 calcium binding protein A3 Protein, S100A3 Protein, S100a3 Protein
    Background

    Background: Protein S100-A3, also known as Protein S-100E, S100 calcium-binding protein A3, S100A3 and S100E, is a member of the S-100 family. S100A3 / S100E contains 2 EF-hand domains. S100A3 / S100E is highly expressed in the differentiating cuticular cells within the hair follicle and organized into mature hair cuticles. High concentrations of S100A3 homotetramer might provide the millimolar level of Ca2+ required for hair cuticular barrier formation. S100A3 / S100E is a unique member of the Ca2+-binding S100 protein family with the highest cysteine content and affinity for Zn2+. S100A3 / S100E binds both calcium and zinc. S100A3 / S100E probably binds 2 zinc ions per molecule. It may be involved in calcium-dependent cuticle cell differentiation and hair shaft formation. S100A3 plays an important role in calcium-dependent processes leading to hair shaft formation. S100A3 / S100E is a unique protein among all members of the calcium-binding S100 family, is specifically expressed at the inner endocuticle of human hair fibers. Upon hair damage, S100A3 / S100E is released from hair fibers and possibly destabilizes the hair tissue architecture.

    Synonym: S100E

    Molecular Weight
    55.3 kDa
    UniProt
    P33764
    Pathways
    S100 Proteins
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