SCGN Protein (His tag)

Catalog No. ABIN7317381

Product Details

Target: SCGN (Secretagogin, EF-Hand Calcium Binding Protein (SCGN))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This SCGN protein is labelled with His tag.

Purpose: Recombinant Human SCGN/Secretagogin Protein (E.coli, His Tag)

Sequence: Asp 2-Pro 276

Characteristics: A DNA sequence encoding the human SCGN (NP_008929.2) (Asp 2-Pro 276) was expressed, with a polyhistide tag at the N-terminus.

Purity: > 97 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SCGN (Secretagogin, EF-Hand Calcium Binding Protein (SCGN))

Alternative Name: SCGN/Secreogin (SCGN Products)

Synonyms: SCGN Protein, MGC146683 Protein, CALBL Protein, DJ501N12.8 Protein, SECRET Protein, SEGN Protein, setagin Protein, zgc:100843 Protein, secretagogin, EF-hand calcium binding protein Protein, Secretagogin Protein, secretagogin, EF-hand calcium binding protein L homeolog Protein, SCGN Protein, scgn Protein, segn Protein, scgn.L Protein, Scgn Protein

Background:

Background: Secretagogin, also known as SCGN, is a secreted protein which is detectable in human serum after ischemic neuronal damage. It is a recently described calcium-binding protein. Secretagogin / SCGN is expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression of Secretagogin / SCGN is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons. Secretagogin / SCGN is widely expressed in prostatic adenocarcinoma as opposed to adenocarcinomas in other organs. The function of Secretagogin / SCGN is unknown, but it has been suggested in beta-cells to influence calcium-influx and has been observed downregulated in diabetes-prone BB rat islets exposed to cytokines. Secretagogin / SCGN is involved in the calcium metabolism of tumour cells and endothelial cells in a subset of neoplasms of the brain and its coverings. Secretagogin / SCGN is also a novel marker for neuroendocrine differentiation.

Synonym: Secretagogin, SCGN, SECRET,CALBL,DJ501N12.8,setagin

Molecular Weight: 33.4 kDa

NCBI Accession: NP_008929