SEMA3A Protein (Fc Tag)

Catalog No. ABIN7320211

Product Details

Target: SEMA3A (Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3A (SEMA3A))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This SEMA3A protein is labelled with Fc Tag.

Purpose: Recombinant Mouse Semaphorin 3A/SEMA3A Protein (Fc Tag)

Sequence: Lys 26-Phe 546

Characteristics: A DNA sequence encoding the N-terminal fragment (Lys 26-Phe 546) of mouse SEMA3A (O08665) was fused with the Fc region of human IgG1 at the N-terminus.

Purity: > 80 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SEMA3A (Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3A (SEMA3A))

Alternative Name: Semaphorin 3A/SEMA3A (SEMA3A Products)

Synonyms: COLL1 Protein, HH16 Protein, Hsema-I Protein, Hsema-III Protein, SEMA1 Protein, SEMAD Protein, SEMAIII Protein, SEMAL Protein, SemD Protein, coll-1 Protein, Semad Protein, COLL-1 Protein, SEMA3A Protein, Dsema3a Protein, Sema3A Protein, sema1a Protein, sema3a1 Protein, semaZ1a Protein, sema1b Protein, sema3a2 Protein, semaZ1b Protein, semaphorin 3A Protein, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A Protein, Sema-3a Protein, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Aa Protein, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab Protein, SEMA3A Protein, Sema3a Protein, Sema-3a Protein, sema3aa Protein, sema3ab Protein

Background:

Background: Semaphorins are a family of secreted and cell-bound signaling molecules defined by the presence of a common 500 aa Sema domain. They are best characterized in relation to axon guidance during development of the nervous system. The functions of Semaphorins 3A (SEMA3A) are mediated primarily through binding to the Neuropilin-1 (Npn-1) and Plexin-A1 coreceptor complex. Neuropilins lack a signaling-competent cytoplasetmic domain and ensure semaphorin binding, whereas the transmembrane receptor plexin mediates the intracellular response. As the first identified vertebrate semaphorin, SEMA3A functions either as a chemorepulsive agent inhibiting axonal outgrowth, or as a chemoattractive agent stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Its overexpression is associated with schizophrenia which is seen in various human tumor cell lines, and aberrant release is associated with the progression of Alzheimer's disease

Synonym: coll-1,Hsema-I,SEMA1,Semad,SemD

Molecular Weight: 87.7 kDa

UniProt: O08665

Pathways: Regulation of Cell Size