SERPINA3N Protein (His tag)
SERPINA3N
Origin: Mouse
Host: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
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- Target See all SERPINA3N Proteins
- SERPINA3N (Serine (Or Cysteine) Peptidase Inhibitor, Clade A, Member 3N (SERPINA3N))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- Human Cells
- Purification tag / Conjugate
- This SERPINA3N protein is labelled with His tag.
- Purpose
- Recombinant Mouse Serpin A3N Protein (His Tag)
- Sequence
- Phe21-Lys418
- Characteristics
- Recombinant Mouse Serpin A3N is produced by our Mammalian expression system and the target gene encoding Phe21-Lys418 is expressed with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl, pH 8.0 .
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- SERPINA3N (Serine (Or Cysteine) Peptidase Inhibitor, Clade A, Member 3N (SERPINA3N))
- Alternative Name
- Serpin A3N (SERPINA3N Products)
- Synonyms
- Spi2-2 Protein, Spi2.2 Protein, Spi2/eb.4 Protein, CPi-26 Protein, SPI3 Protein, Spi-2.2 Protein, Spin2c Protein, Spin3 Protein, serine (or cysteine) peptidase inhibitor, clade A, member 3N Protein, Serpina3n Protein
- Background
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Background: Serine protease inhibitor A3N(Serpin A3N) is a serine protease inhibitor that is structurally related to α1 antichymotrypsin encoded by the SERPINA3 gene. Serpin A3N is highly expressed in brain, testis, lung, thymus, and spleen. It is expressed with low levels in bone marrow, kidney and skeletal muscle. Serpin A3N secreted by Sertoli cells may regulate the activity of locally produced Granzyme B. Granzyme B inhibition by Serpin A3N may therefore regulate Granzyme Bmediated killing by cytotoxic lymphocytes, providing a means to disable cellmediated immune responses.
Synonym: Serine protease inhibitor A3N, Serpin A3N, Serpina3n, Spi2
- Molecular Weight
- 45.6 kDa
- UniProt
- Q91WP6
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