SERPINA6 Protein (His tag)
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- Target See all SERPINA6 Proteins
- SERPINA6 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This SERPINA6 protein is labelled with His tag.
- Purpose
- Recombinant Mouse SerpinA6/CBG Protein (His Tag)
- Sequence
- Met 1-Ala 397
- Characteristics
- A DNA sequence encoding the mouse SERPINA6 (Q06770) (Met 1-Ala 397) was fused with a polyhistidine tag at the C-terminus.
- Purity
- > 98 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product SERPINA6 Protein
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serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6) (AA 23-405) protein (GST tag)
SERPINA6 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6) (AA 23-405) protein (His tag)Crystallography grade SERPINA6 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6) (AA 23-397) protein (His tag)Crystallography grade SERPINA6 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- SERPINA6 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6))
- Alternative Name
- SerpinA6/CBG (SERPINA6 Products)
- Synonyms
- ep45-A Protein, SERPINA6 Protein, AI265318 Protein, AV104445 Protein, Cbg Protein, CBG Protein, serpin family A member 6 Protein, serpin family A member 6 L homeolog Protein, corticosteroid-binding globulin Protein, serine (or cysteine) peptidase inhibitor, clade A, member 6 Protein, SERPINA6 Protein, serpina6.L Protein, LOC490838 Protein, Serpina6 Protein
- Background
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Background: Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90 % of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.
Synonym: AI265318,AV104445,Cbg
- Molecular Weight
- 43.7 kDa
- UniProt
- Q06770
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