SERPINB6 Protein (His tag)

Catalog No. ABIN7317335

Product Details

Target: SERPINB6 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 6 (SERPINB6))

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This SERPINB6 protein is labelled with His tag.

Purpose: Recombinant Human SerpinB6/PI-6 Protein (His Tag)

Sequence: Asp 2-Pro 376

Characteristics: A DNA sequence encoding the human SERPINB6 (AAB30320.1) (Asp 2-Pro 376) was expressed, with a polyhistidine tag at the N-terminus.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SERPINB6 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 6 (SERPINB6))

Alternative Name: SerpinB6/PI-6 (SERPINB6 Products)

Synonyms: Serpinb6a Protein, cap Protein, dfnb91 Protein, mstp057 Protein, pi6 Protein, pti Protein, serpinb8 Protein, spi3 Protein, 4930482L21Rik Protein, D330015H01Rik Protein, PI-6 Protein, Serpinb6 Protein, Spi3 Protein, ovalbumin Protein, CAP Protein, DFNB91 Protein, MSTP057 Protein, PI6 Protein, PTI Protein, SPI3 Protein, serpin family B member 6A Protein, serpin family B member 6 Protein, serine (or cysteine) peptidase inhibitor, clade B, member 6a Protein, serpin peptidase inhibitor, clade B (ovalbumin), member 6 Protein, Serpinb6a Protein, serpinb6 Protein, SERPINB6 Protein

Background:

Background: SerpinB6, also known as Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental thrombin inhibitor, SERPINB6 and PI-6, is a cytoplasm protein which belongs to the serpin family and Ov-serpin subfamily. SerpinB6 / PI-6 is an inhibitor of cathepsin G, kallikrein-8 and thrombin. It may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. SerpinB6 / PI-6 is expressed in keratinocytes (at protein level). It is also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. SerpinB6 / PI-6 is expressed in the inner ear hair cells. It expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions. SerpinB6 / PI-6 may be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Defects in SerpinB6 are the cause of deafness autosomal recessive type 91 which is a form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.

Synonym: Serpin B6; Cytoplasmic Antiproteinase; CAP; Peptidase Inhibitor 6; PI-6; Placental Thrombin Inhibitor; SERPINB6; PI6; PTI;PI-6;PTI;RP1-90J20.6;SPI3

Molecular Weight: 44.9 kDa