SAA2 Protein (His tag)

Catalog No. ABIN7319467

Product Details

Target: SAA2 (Serum Amyloid A2 (SAA2))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This SAA2 protein is labelled with His tag.

Purpose: Recombinant Human SAA2/Serum Amyloid A2 Protein (His Tag)

Sequence: Arg19-Tyr122

Characteristics: Recombinant Human Serum amyloid A-2 protein is produced by our E.coli expression system and the target gene encoding Arg19-Tyr122 is expressed with a 6His tag at the N-terminus.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mMPB,150 mMNaCl, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SAA2 (Serum Amyloid A2 (SAA2))

Alternative Name: SAA2/Serum Amyloid A2 (SAA2 Products)

Synonyms: SAA2 Protein, DKFZp470K0711 Protein, SAA Protein, SAA1 Protein, AW111173 Protein, Saa-2 Protein, Saa1 Protein, serum amyloid A protein Protein, serum amyloid protein A Protein, serum amyloid A2 Protein, serum amyloid A 2 Protein, serum amyloid A-2 protein Protein, LOC476879 Protein, LOC100009259 Protein, SAA2 Protein, Saa2 Protein

Background:

Background: Serum amyloid A-2 protein (SAA2) belongs to the SAA family. It expressed by the liver and secreted in plasma. SAA2 functions as major acute phase reactant and could works as apolipoprotein of the HDL complex. Increased levels of A-SAA in serum are indicative of inflammatory disease. When highly expressed, SAA can displace ApoA1 as the major apolipoprotein in HDL complexes, weakening the function of HDL as a reverse (lipid clearing) cholesterol transporter. A highly charged region of SAA2 and SAA1 (aa 36-68) contains putative fibronectin- and laminin-binding motifs. This region also binds heparin sulfate proteoglycans at mildly acidic pH and promotes aggregation of A-SAA.

Synonym: SAA, SAA2, Serum Amyloid A2

Molecular Weight: 13.2 kDa

UniProt: P0DJI9

Pathways: Toll-Like Receptors Cascades