SGK3 Protein (GST tag,His tag)

Catalog No. ABIN7317498

Product Details

Target: SGK3 (serum/glucocorticoid Regulated Kinase Family, Member 3 (SGK3))

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This SGK3 protein is labelled with GST tag,His tag.

Purpose: Recombinant Human SGK3/SGKL Protein (His & GST Tag)

Sequence: Met 1-Leu 496

Characteristics: A DNA sequence encoding the human SGK3 (Q96BR1-1) (Met 1-Leu 496) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Purity: > 80 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 0.5 mM PMSF, 10 % glycerol, 1 mM GSH, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SGK3 (serum/glucocorticoid Regulated Kinase Family, Member 3 (SGK3))

Alternative Name: SGK3/SGKL (SGK3 Products)

Synonyms: CISK Protein, SGK2 Protein, SGKL Protein, 2510015P22Rik Protein, A330005P07Rik Protein, Cisk Protein, fy Protein, fz Protein, Sgkl Protein, zgc:162253 Protein, serum/glucocorticoid regulated kinase family member 3 Protein, serum/glucocorticoid regulated kinase 3 Protein, serum/glucocorticoid regulated kinase family, member 3 Protein, serine/threonine-protein kinase Sgk3 Protein, SGK3 Protein, Sgk3 Protein, LOC464217 Protein, sgk3 Protein, LOC100231693 Protein, LOC100343709 Protein, LOC100052030 Protein, LOC100521447 Protein

Background:

Background: Serine / threonine-protein kinase Sgk3, also known as Serum / glucocorticoid-regulated kinase 3, Serum / glucocorticoid-regulated kinase-like and SGK3, is a cytoplasmic vesicle protein which belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. SGK3 contains one AGC-kinase C-terminal domain, one protein kinase domain and one PX (phox homology) domain. Two specific sites of SGK3, one in the kinase domain (Thr-320) and the other in the C-terminal regulatory region (Ser-486), is needed to be phosphorylated for its full activation. SGK3 is expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. SGK3 is involved in the activation of potassium channels. It mediates cell IL-3-dependent survival signals. SGK3 participates in the regulation of HERG by increasing HERG protein abundance in the plasma membrane and may thus modify the duration of the cardiac action potential. SGK3 is also a very important and characteristic molecule that plays a critical role in both hair follicle morphogenesis and hair cycling.

Synonym: CISK;SGK2;SGKL

Molecular Weight: 85 kDa