SLAMF8 Protein (His tag)

Catalog No. ABIN7320649

Product Details

Target: SLAMF8 (SLAM Family Member 8 (SLAMF8))

Protein Type: Recombinant

Origin: Mouse

Source: Human Cells

Purification tag / Conjugate: This SLAMF8 protein is labelled with His tag.

Purpose: Recombinant Mouse SLAMF8 Protein (His Tag)

Sequence: Val21-Asp231

Characteristics: Recombinant Mouse SLAM Family Member 8 is produced by our Mammalian expression system and the target gene encoding Val21-Asp231 is expressed with a 6His tag at the C-terminus.

Purity: > 80 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SLAMF8 (SLAM Family Member 8 (SLAMF8))

Alternative Name: SLAMF8 (SLAMF8 Products)

Synonyms: BLAME Protein, CD353 Protein, SBBI42 Protein, 5830408F06Rik Protein, Blame Protein, SLAM family member 8 Protein, Slamf8 Protein, slamf8 Protein, SLAMF8 Protein

Background:

Background: Mouse SLAM family member 8/SLAMF8 is a single-pass type I membrane protein. It contains one Ig-likeC2-type domain. SLAMF8 is expressed in lymphnode, spleen, thymus and bone marrow. The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. SLAM family of receptors is expressed by a wide range of immune cells. Through their cytoplasmic domain, SLAM family receptors associate with SLAM-associated protein (SAP)-related molecules, a group of cytoplasmic adaptors composed almost exclusively of an SRC homology 2 domain. SLAM family receptors, inassociation with SAP family adaptors, have crucial roles during normal immune reactions in innate and adaptive immune cells. It may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.

Synonym: SLAM family member 8, B-lymphocyte activator macrophage expressed, CD353, Slamf8, Blame,SBBI42

Molecular Weight: 24.2 kDa

UniProt: Q9D3G2