SMAD1 Protein (GST tag)

Catalog No. ABIN7319041

Product Details

Target: SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This SMAD1 protein is labelled with GST tag.

Purpose: Recombinant Human SMAD1 Protein (GST Tag)

Sequence: Met 1-Ser465

Characteristics: Recombinant Human Mothers Against Decapentaplegic Homolog 1 is produced by our E.coli expression system and the target gene encoding Met1-Ser465 is expressed with a GST tag at the N-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0 .

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))

Alternative Name: SMAD1 (SMAD1 Products)

Synonyms: MLP Protein, Xmad1 Protein, Xsmad1 Protein, bsp1 Protein, jv4-1 Protein, jv41 Protein, madh1 Protein, madr1 Protein, smad-1 Protein, MADH1 Protein, fb39h09 Protein, wu:fb39h09 Protein, wu:fb97e04 Protein, 2/23 Protein, CG12399 Protein, Dmel\\CG12399 Protein, E(zen)2 Protein, En(vvl) Protein, MAD Protein, Mat Protein, P-Mad Protein, P-mad Protein, PMad Protein, Smad Protein, Smad1 Protein, apg Protein, c28 Protein, dMAD Protein, dMad Protein, l(2)K00237 Protein, l(2)k00237 Protein, mad Protein, p-Mad Protein, pMAD Protein, pMad Protein, pSmad Protein, BSP-1 Protein, BSP1 Protein, JV4-1 Protein, JV41 Protein, MADR1 Protein, AI528653 Protein, Madh1 Protein, Madr1 Protein, Mlp1 Protein, MusMLP Protein, smad1 Protein, xmad Protein, SMAD family member 1 Protein, Mothers against dpp Protein, SMAD family member 1 L homeolog Protein, smad1 Protein, SMAD1 Protein, Mad Protein, Smad1 Protein, smad1.L Protein

Background:

Background: SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death.

Synonym: Mothers Against Decapentaplegic Homolog 1, MAD Homolog 1, Mothers Against DPP Homolog 1, JV4-1, Mad-Related Protein 1, SMAD Family Member 1,Transforming Growth Factor-Beta-Signaling Protein 1, BSP-1, SMAD1, BSP1, MADH1,SMAD 1,Smad1,hSMAD1,MADR1

Molecular Weight: 78.7 kDa

UniProt: Q15797

Pathways: Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development