SUMO2 Protein (His tag)

Catalog No. ABIN7319043

Product Details

Target: SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This SUMO2 protein is labelled with His tag.

Purpose: Recombinant Human SUMO2 Protein (His Tag)

Sequence: Met 1-Gly93

Characteristics: Recombinant Human Small Ubiquitin-Related Modifier 2 is produced by our E.coli expression system and the target gene encoding Met1-Gly93 is expressed with a 6His tag at the N-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

Alternative Name: SUMO2 (SUMO2 Products)

Synonyms: HSMT3 Protein, SMT3B Protein, SMT3H2 Protein, SUMO3 Protein, Smt3A Protein, SMT3A Protein, SMT3H1 Protein, SUMO-3 Protein, Smt3B Protein, Smt3h2 Protein, sumo2 Protein, zgc:92241 Protein, SUMO2 Protein, SUMO-2 Protein, Smt3b Protein, hsmt3 Protein, smt3b Protein, smt3h2 Protein, sumo-2 Protein, PSMT3 Protein, ATSUMO2 Protein, MCO15.11 Protein, MCO15_11 Protein, SMALL UBIQUITIN-LIKE MODIFIER 2 Protein, SUM2 Protein, SUMO 2 Protein, small ubiquitin-like modifier 2 Protein, small ubiquitin-like modifier 2 Protein, small ubiquitin-like modifier 3 Protein, small ubiquitin-like modifier 2b Protein, small ubiquitin-related modifier 2 Protein, small ubiquitin-like modifier 2 S homeolog Protein, small ubiquitin-like modifier 2 L homeolog Protein, SUMO2 Protein, SUMO3 Protein, Sumo2 Protein, sumo2b Protein, LOC714892 Protein, sumo2.S Protein, sumo2.L Protein

Background:

Background: Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. SUMO2 can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptidebond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

Synonym: Small Ubiquitin-Related Modifier 2, SUMO-2, HSMT3, SMT3 homolog 2, SUMO-3, Sentrin-2, Ubiquitin-Like Protein SMT3A, Smt3A, SUMO2, SMT3A, SMT3H2

Molecular Weight: 13.0 kDa

Pathways: Methionine Biosynthetic Process