SUMO1 Protein (His tag)

Catalog No. ABIN7317307

Product Details

Target: SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This SUMO1 protein is labelled with His tag.

Purpose: Recombinant Human SUMO1 Protein (His Tag)(Active)

Sequence: Ser 2-Val 101

Characteristics: A DNA sequence encoding the human SUMO1 (AAH66306.1) (Ser 2-Val 101) was expressed, with a polyhistide tag at the N-terminus.

Purity: > 90 % as determined by reducing SDS-PAGE.

Biological Activity Comment: Measured by its ability to be proteolytically processed by SENP1.>50% of 1 μg Recombinant Human (rh) SUMO1 is cleaved by < 10 ng of recombinant human SENP.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.5

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

Alternative Name: SUMO1 (SUMO1 Products)

Synonyms: DAP1 Protein, GMP1 Protein, OFC10 Protein, PIC1 Protein, SENP2 Protein, SMT3 Protein, SMT3C Protein, SMT3H3 Protein, UBL1 Protein, hm:zeh0670 Protein, wu:fb74c02 Protein, wu:fd12c02 Protein, zgc:65934 Protein, zgc:85634 Protein, SUMO1 Protein, dap1 Protein, gmp1 Protein, ofc10 Protein, pic1 Protein, senp2 Protein, smt3 Protein, smt3c Protein, sumo-1 Protein, sumo1 Protein, ubl1 Protein, xsumo-1 Protein, xsumo1 Protein, ARABIDOPSIS THALIANA SMALL UBIQUITIN-LIKE MODIFIER 1 Protein, ATSUMO1 Protein, F10M23.180 Protein, F10M23_180 Protein, SMALL UBIQUITIN-LIKE MODIFIER 1 Protein, SUM1 Protein, SUMO 1 Protein, small ubiquitin-like modifier 1 Protein, pigSUMO1 Protein, SENTRIN Protein, SMTP3 Protein, SUMO-1 Protein, Smt3C Protein, Ubl1 Protein, small ubiquitin-like modifier 1 Protein, small ubiquitin-like modifier 1 S homeolog Protein, small ubiquitin-related protein 1 Protein, SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) Protein, SMT3 suppressor of mif two 3 homolog 1 (yeast) Protein, small ubiquitin-like modifier 1 L homeolog Protein, Sumo1 Protein, SUMO1 Protein, sumo1 Protein, sumo1.S Protein, sumo-1 Protein, sumo1.L Protein

Background:

Background: Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation. SUMO1 plays an important role in modulation of NOX activity required for ROS generation. SUMO1 haploinsufficiency results in cleft lip and palate in animal models. SUMO1 gene variation in human non-syndromic cleft lip with or without cleft palate (NSCLP) development. SUMO-1 may be useful as a novel target for therapy in oral squamous cell carcinoma (SCC) as well as a clinical indicator for tumor recurrence together with Mdm2.

Synonym: Small Ubiquitin-Related Modifier 1, SUMO-1, GAP-Modifying Protein 1, GMP1, SMT3 Homolog 3, Sentrin, Ubiquitin-Homology Domain Protein PIC1, Ubiquitin-Like Protein SMT3C, Smt3C, Ubiquitin-Like Protein,UBL1, SUMO1, SMT3C, SMT3H3, UBL1,DAP1,OFC10,SENP2,SMT3

Molecular Weight: 12.4 kDa

Pathways: M Phase, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, Ubiquitin Proteasome Pathway