TFAP2C Protein (His tag)

Catalog No. ABIN7317304

Product Details

Target: TFAP2C (Transcription Factor AP-2 gamma (Activating Enhancer Binding Protein 2 Gamma) (TFAP2C))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This TFAP2C protein is labelled with His tag.

Purpose: Recombinant Human TFAP2C/AP2-GAMMA Protein (His Tag)

Sequence: Leu128-Val223

Characteristics: A DNA sequence encoding the mature form of human TFAP2C (Q92754) (Leu128-Val223) was expressed with a polyhistide tag at the N-terminus.

Purity: > 98 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: TFAP2C (Transcription Factor AP-2 gamma (Activating Enhancer Binding Protein 2 Gamma) (TFAP2C))

Alternative Name: TFAP2C/AP2-GAMMA (TFAP2C Products)

Synonyms: erf1 Protein, hap-2g Protein, tfa2pc Protein, tfap2g Protein, ap2-gamma Protein, TFAP2C Protein, AP2-gamma Protein, Tcfap2c Protein, AP2-GAMMA Protein, ERF1 Protein, TFAP2G Protein, hAP-2g Protein, wu:fb48g05 Protein, wu:fb49c04 Protein, zgc:92088 Protein, ap-2g Protein, tfap2gamma Protein, AA409384 Protein, AP2gamma Protein, Ap-2.2 Protein, Stra2 Protein, transcription factor AP-2 gamma Protein, putative transcription factor ap-2 gamma Protein, transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) Protein, transcription factor AP-2 gamma S homeolog Protein, transcription factor AP-2, gamma Protein, tfap2c Protein, TFAP2C Protein, Smp_157840 Protein, Tfap2c Protein, tfap2c.S Protein

Background:

Background: TFAP2C, also known as AP2-GAMMA, is a member of the activating protein 2 family of transcription factors. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2C may be prognostic indicators for patients with breast tumors. TFAP2C gene has been tested for association to diseases (Breast Neoplasms, Carcinoma) and proposed to participate in processes (cell-cell signaling, male gonad development, regulation of transcription from RNA polymerase II promoter). Proteins are expected to have molecular functions (DNA binding, protein binding, protein dimerization activity, transcription factor activity) and to localize in various compartments (membrane, nucleus).

Synonym: AP2-GAMMA,ERF1,hAP-2g,TFAP2G

Molecular Weight: 12.3 kDa

UniProt: Q92754

Pathways: Stem Cell Maintenance