CD300LB Protein (Fc Tag)

Catalog No. ABIN7319809

Product Details

Target: CD300LB (TREM5) (Triggering Receptor Expressed On Myeloid Cells 5 (TREM5))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This CD300LB protein is labelled with Fc Tag.

Purpose: Recombinant Human CD300LB/LMIR5 (C-Fc)

Sequence: Ile55-His187

Characteristics: Recombinant Human CD300LB is produced by our Mammalian expression system and the target gene encoding Ile55-His187 is expressed with a Fc tag at the C-terminus.

Purity: >95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CD300LB (TREM5) (Triggering Receptor Expressed On Myeloid Cells 5 (TREM5))

Alternative Name: CD300LB/LMIR5 (TREM5 Products)

Synonyms: CLM-7 Protein, Clm7 Protein, Gm253 Protein, LMIR5 Protein, CD300b Protein, CLM7 Protein, CMRF35-A2 Protein, IREM-3 Protein, IREM3 Protein, TREM-5 Protein, TREM5 Protein, CD300 molecule like family member B Protein, CD300 molecule like family member b Protein, triggering receptor expressed on myeloid cells 5 Protein, Cd300lb Protein, CD300LB Protein, Trem5 Protein

Background:

Background: CD300LB, also known as CD300b, LMIR5, CLM-7, and IREM-3, is a glycoprotein member of the immunoglobulin superfamily. LMIR5 is expressed on the surface of myeloid lineage cells. It forms noncovalent cis-homodimers and cis-heterodimers with other CD300 family proteins, and the composition of these dimers affects the cellular response. Antibody cross-linking of LMIR5 induces mast cell granule release and cytokine production as well as its tyrosine phosphorylation of LMIR5 (in human). LMIR5 interacts with TIM1 and TIM4 which regulate T cell activation and are themselves binding partners. TIM1 interactions with LMIR5 mediate mast cell activation and the accumulation of neutrophils at sites of TIM1 up-regulation on damaged renal tubule epithelial cells. Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.

Synonym: CD300b, CLM-7, CLM-7, CMRF35-A2, IREM-3, IREM3, TREM-5, TREM5, CD300LB

Molecular Weight: 42.2 kDa