Tryptophan Hydroxylase 2 Protein (TPH2) (His tag)
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- Target See all Tryptophan Hydroxylase 2 (TPH2) Proteins
- Tryptophan Hydroxylase 2 (TPH2)
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Tryptophan Hydroxylase 2 protein is labelled with His tag.
- Purpose
- Recombinant Human TPH2 Protein (His Tag)
- Sequence
- Met 1-Ile496
- Characteristics
- Recombinant Human Tryptophan 5-Hydroxylase 2 is produced by our E.coli expression system and the target gene encoding Met1-Ile496 is expressed with a 6His tag at the N-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product TPH2 Protein
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Tryptophan Hydroxylase 2 (TPH2) (AA 151-466) protein (His tag)
TPH2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Tryptophan Hydroxylase 2 (TPH2) (AA 1-490) protein (Strep Tag)Crystallography grade TPH2 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Tryptophan Hydroxylase 2 (TPH2) (AA 1-488) protein (Strep Tag)Crystallography grade TPH2 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Tryptophan Hydroxylase 2 (TPH2) protein (Myc-DYKDDDDK Tag)TPH2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- Tryptophan Hydroxylase 2 (TPH2)
- Alternative Name
- TPH2 (TPH2 Products)
- Synonyms
- ADHD7 Protein, NTPH Protein, Ntph Protein, tphR Protein, wu:fq15a04 Protein, AU043594 Protein, tryptophan hydroxylase 2 Protein, tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) Protein, TPH2 Protein, Tph2 Protein, tph2 Protein
- Background
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Background: Tryptophan 5-hydroxylase 2 (TPH2) is an isozyme member of the biopterin-dependent aromatic amino acid hydroxylase family. TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression found in the raphe nucleus of the midbrain. TPH2 catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD). Defects in TPH2 are the cause of psychiatric diseases such as bipolar affective disorder and major depression.
Synonym: Tryptophan 5-Hydroxylase 2, Neuronal Tryptophan Hydroxylase, Tryptophan 5-Monooxygenase 2, TPH2, NTPH
- Molecular Weight
- 58.8 kDa
- UniProt
- Q14CC5
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