Tyrosinase-Related Protein 1 Protein (TYRP1) (His tag)

Catalog No. ABIN7317285

Product Details

Target: Tyrosinase-Related Protein 1 (TYRP1)

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Tyrosinase-Related Protein 1 protein is labelled with His tag.

Purpose: Recombinant Human TRP1/TYRP1 Protein (Human Cells, His Tag)

Sequence: Met 1- Arg 471

Characteristics: A DNA sequence encoding the human TYRP1 (P17643) extracellular domain (Met 1- Arg 471) was fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Tyrosinase-Related Protein 1 (TYRP1)

Alternative Name: /TYRP1 (TYRP1 Products)

Synonyms: CAS2 Protein, CATB Protein, GP75 Protein, OCA3 Protein, TRP Protein, TRP1 Protein, TYRP Protein, b-PROTEIN Protein, LOC397853 Protein, Trypsin Protein, hm:zeh0659 Protein, tyrp1 Protein, zgc:100893 Protein, B Protein, TYRP1 Protein, tyrp-1 Protein, TRP-1 Protein, Tyrp Protein, b Protein, brown Protein, isa Protein, tyrosinase related protein 1 Protein, protease, serine 1 L homeolog Protein, tyrosinase-related protein 1b Protein, tyrosinase-related protein 1 Protein, tyrosinase-related protein 1 L homeolog Protein, tyrosinase-related protein 1a Protein, TYRP1 Protein, prss1.L Protein, tyrp1b Protein, Tyrp1 Protein, tyrp1.L Protein, tyrp1 Protein, LOC100136490 Protein, tyrp-1 Protein, tyrp1a Protein

Background:

Background: Tyrosinase-related protein 1, also known as TYRP1 or TRP1, is a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Mutations in this enzyme are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. TYRP1 / TRP1 is involved in the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. This enzyme may regulate or influence the type of melanin synthesized. The expression of Tyrosinase-related protein 1 (TYRP1) is regulated by the microphthalmia-associated transcription factor (MITF). There is mounting evidence demonstrating that in addition to its role in eumelanin synthesis, TYRP1 is involved in maintaining stability of tyrosinase proliferation and melanocyte cell death.

Synonym: b-PROTEIN,CAS2,CATB,GP75,OCA3,TRP,TRP1,TYRP

Molecular Weight: 52.2 kDa

UniProt: P17643