BTN3A1 Protein (Biotin)
Quick Overview for BTN3A1 Protein (Biotin) (ABIN7319892)
Target
See all BTN3A1 ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This BTN3A1 protein is labelled with Biotin.
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Purpose
- Recombinant Human Butyrophilin Subfamily 3 Member A1/BTN3A1 (C-Fc-Avi) Biotinylated
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Sequence
- Gln30-Gly254
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Characteristics
- Biotinylated Recombinant Human Butyrophilin Subfamily 3 Member A1 is produced by our Mammalian expression system and the target gene encoding Gln30-Gly254 is expressed with a Fc, Avi tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Comment
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58-62 kDa
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- BTN3A1 (Butyrophilin, Subfamily 3, Member A1 (BTN3A1))
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Alternative Name
- BTN3A1
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Background
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Background: Butyrophilin Subfamily 3 Member A1 (BTN3A1/CD277) is a type I transmembrane glycoprotein member of the Ig superfamily. It is expressed on a wide variety of immune cells. Similar to BTN3A2 and BTN3A3, BTN3A1 is composed of an extracellular N-terminal IgV and a membraneproximal IgC domain followed by a transmembrane domain and a cytoplasmic tail. These Ig domains are also found in B7 family costimulatory molecules, suggesting structural and functional similarities between the two protein families. BTN3A1 acts as a critical protein for the activation of Vγ9Vδ2 T cells following detection of distressed cells. The anti-tumor responses of Vγ9Vδ2 T cells may be enhanced with agonistic anti-BTNA3 antibodies.
Synonym: Butyrophilin subfamily 3 member A1, CD277, BTN3A1, BTF5
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Molecular Weight
- 52.6 kDa
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UniProt
- O00481
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Pathways
- Activated T Cell Proliferation
Target
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