ADAM8 Protein (AA 17-658) (His tag)

Catalog No. ABIN7273803

Product Details

Target: ADAM8 (ADAM Metallopeptidase Domain 8 (ADAM8))

Protein Type: Recombinant

Protein Characteristics: AA 17-658

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This ADAM8 protein is labelled with His tag.

Purpose: Mouse ADAM8 Protein

Sequence: Pro17-Ser658

Characteristics: Recombinant Mouse ADAM8 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Pro17-Ser658.

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: ADAM8 (ADAM Metallopeptidase Domain 8 (ADAM8))

Alternative Name: ADAM8 (ADAM8 Products)

Synonyms: CD156 Protein, MS2 Protein, CD156a Protein, E430039A18Rik Protein, adam8 Protein, reprolysin Protein, si:zc217g15.7 Protein, zgc:64059 Protein, ADAM8 Protein, RGD1566394 Protein, ADAM metallopeptidase domain 8 Protein, a disintegrin and metalloproteinase domain 8 Protein, a disintegrin and metallopeptidase domain 8 Protein, ADAM metallopeptidase domain 8a Protein, ADAM8 Protein, LOC100304737 Protein, Adam8 Protein, adam8a Protein, adam8 Protein

Background: A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer.

Molecular Weight: 71.7 kDa. Due to glycosylation, the protein migrates to 55-65 kDa and 35-45 kDa based on Tris-Bis PAGE result.

UniProt: Q05910

Pathways: Activation of Innate immune Response, M Phase