IL17 Receptor B Protein (AA 18-292) (His tag)
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- Target See all IL17 Receptor B (IL17RB) Proteins
- IL17 Receptor B (IL17RB) (Interleukin 17 Receptor B (IL17RB))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 18-292
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IL17 Receptor B protein is labelled with His tag.
- Purpose
- Human IL-17RB Protein
- Sequence
- Arg18-Per292
- Characteristics
- Recombinant Human IL-17RB Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Arg18-Per292.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human IL-17RB, His Tag at 0.2μg/ml (100μl/well) on the plate. Dose response curve for Anti-IL-17RB Antibody, hFc Tag with the EC50 of 4.4ng/ml determined by ELISA. The affinity constant of 0.81 nM as determined in SPR assay (Biacore T200). See testing image for detail.
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Interleukin 17 Receptor B (IL17RB) (AA 18-286) protein (His tag)
IL17RB Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 17 Receptor B (IL17RB) (AA 317-494) protein (His-IF2DI Tag)IL17RB Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 17 Receptor B (IL17RB) (AA 18-117) protein (GST tag)IL17RB Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 17 Receptor B (IL17RB) (Active) protein (His tag)IL17RB Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Interleukin 17 Receptor B (IL17RB) (AA 18-292) protein (His tag)Crystallography grade IL17RB Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Interleukin 17 Receptor B (IL17RB) (AA 314-502) protein (His tag)Crystallography grade IL17RB Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Interleukin 17 Receptor B (IL17RB) (AA 18-286) protein (His tag)Crystallography grade IL17RB Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Interleukin 17 Receptor B (IL17RB) (AA 308-499) protein (His tag)Crystallography grade IL17RB Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Interleukin 17 Receptor B (IL17RB) (AA 18-502) protein (rho-1D4 tag)Crystallography grade IL17RB Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Interleukin 17 Receptor B (IL17RB) (AA 18-499) protein (rho-1D4 tag)Crystallography grade IL17RB Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- IL17 Receptor B (IL17RB) (Interleukin 17 Receptor B (IL17RB))
- Alternative Name
- IL-17RB (IL17RB Products)
- Synonyms
- IL17RB Protein, CRL4 Protein, EVI27 Protein, IL17BR Protein, IL17RH1 Protein, Evi27 Protein, IL-17ER Protein, IL-17Rh1 Protein, Il17br Protein, interleukin 17 receptor B Protein, IL17RB Protein, Il17rb Protein
- Background
- Among inflammatory mediators, a growing body of evidence emphasizes the contribution of the interleukin 17 (IL-17) cytokine family in malignant diseases. Besides IL-17A, the prototypic member of the IL-17 family, several experimental findings strongly support the role of the IL-17B/IL-17 receptor B (IL-17RB) pathway in tumorigenesis and resistance to anticancer therapies. In mouse models, IL-17B signaling through IL-17RB directly promotes cancer cell survival, proliferation, and migration, and induces resistance to conventional chemotherapeutic agents.
- Molecular Weight
- 31.4 kDa. Due to glycosylation, the protein migrates to 45-60 kDa based on Tris-Bis PAGE result.
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