IL17RC Protein (AA 21-467) (hFc Tag)

Catalog No. ABIN7274895

This Recombinant IL17RC protein is produced in HEK-293 Cells.

Quick Overview for IL17RC Protein (AA 21-467) (hFc Tag) (ABIN7274895)

Target: IL17RC (Interleukin 17 Receptor C (IL17RC))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purity: > 95 % as determined by Bis-Tris PAGE

Product Details

Protein Characteristics: AA 21-467

Purification tag / Conjugate: This IL17RC protein is labelled with hFc Tag.

Purpose: Human IL-17Rc Protein

Sequence: Leu21-Arg467

Characteristics: Recombinant Human IL-17Rc Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Leu21-Arg467.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1 EU per μg by the LAL method.

Biological Activity Comment: Immobilized Human IL-17A, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Human IL-17Rc, hFc Tag with the EC50 of 54.6ng/ml determined by ELISA.,Immobilized Human IL-25, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IL-17Rc, hFc Tag with the EC50 of 4.64ug/ml determined by ELISA,Human IL-17Rc on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1 mg/mL for 500 μg or 1 mg lyophilized powder. Do not mix by vortex or vigorous shaking.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3 months after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: IL17RC (Interleukin 17 Receptor C (IL17RC))

Alternative Name: IL-17Rc

Background: IL-17RC (interleukin-17 receptor-like) gene codes for a transmembrane protein, the full length of which inhibits apoptosis in prostate cancer cells. IL-17RC gene transcribes over a dozen different splice variants of mRNA. IL-17RC protein isoforms are differentially expressed in prostatic cells and cancer tissues and may play a negative or positive role in the initiation and progression of prostate cancer.

Molecular Weight: 76.2 kDa. Due to glycosylation, the protein migrates to 95-135 kDa based on Bis-Tris PAGE result.

NCBI Accession: NP_703190