MUC1 Protein (AA 24-158) (hFc Tag)

Catalog No. ABIN7275298

This Recombinant MUC1 protein is expressed in HEK-293 Cells.

Quick Overview for MUC1 Protein (AA 24-158) (hFc Tag) (ABIN7275298)

Target: MUC1 (Mucin 1 (MUC1))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purity: > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC

Product Details

Protein Characteristics: AA 24-158

Purification tag / Conjugate: This MUC1 protein is labelled with hFc Tag.

Purpose: Human Mucin-1/MUC-1 Isoform Y Protein

Sequence: Ser24-Gly158

Characteristics: Recombinant Human Mucin-1 Isoform Y Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Ser24-Gly158.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1 EU per μg by the LAL method.

Biological Activity Comment: Human Mucin-1 Isoform Y on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.,The purity of Human Mucin-1 Isoform Y is greater than 95% as determined by SEC-HPLC.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1 mg/mL for 500 μg or 1 mg lyophilized powder. Do not mix by vortex or vigorous shaking.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3 months after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: MUC1 (Mucin 1 (MUC1))

Alternative Name: MUC1

Background: MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire variable number of tandem repeat region, are involved in oncogenic processes by enhancing tumour initiation. MUC1/Y is therefore considered a promising target for the identification and treatment of epithelial cancers.

Molecular Weight: 41.38 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.

UniProt: P15941

Pathways: Negative Regulation of intrinsic apoptotic Signaling