TTR Protein (AA 21-147) (His tag)

Catalog No. ABIN7275811

Product Details

Target: TTR (Transthyretin (TTR))

Protein Type: Recombinant

Protein Characteristics: AA 21-147

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This TTR protein is labelled with His tag.

Purpose: Human Transthyretin/Prealbumin Protein

Sequence: Gly21-Glu147

Characteristics: Recombinant Human Transthyretin/Prealbumin Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly21-Glu147.

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: TTR (Transthyretin (TTR))

Alternative Name: Transthyretin (TTR Products)

Synonyms: zgc:103583 Protein, TTR Protein, LOC100226992 Protein, CTS Protein, CTS1 Protein, HsT2651 Protein, PALB Protein, TBPA Protein, AA408768 Protein, AI787086 Protein, D17860 Protein, prealbumin Protein, Lr1 Protein, Tbpa Protein, Prealbumin Protein, xTTR Protein, transthyretin (prealbumin, amyloidosis type I) Protein, transthyretin Protein, Transthyretin Protein, transthyretin (prealbumin, amyloidosis type 1) Protein, transthyretin-like Protein, transthyretin L homeolog Protein, ttr Protein, TTR Protein, vpb38 Protein, MRAD2831_RS38185 Protein, Caci_4246 Protein, LOC100226992 Protein, Ttr Protein, ttr.L Protein

Background: Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver and the choroid plexus of brain. The carrier role of TTR is well-known, however, many other functions have emerged, namely in the nervous system. TTR aggregates are responsible for many amyloidosis such as familial amyloidotic polyneuropathy and cardiomyopathy. Normal TTR can also aggregate and deposit in the heart of old people and in preeclampsia placental tissue.

Molecular Weight: 14.9 kDa. Due to glycosylation, the protein migrates to 16 kDa and 39 kDa based on Tris-Bis PAGE result.

NCBI Accession: NP_000362

Pathways: Hormone Transport