CDH10 Protein (His tag)

Catalog No. ABIN7491297

Product Details

Target: CDH10 (Cadherin 10, Type 2 (T2-Cadherin) (CDH10))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This CDH10 protein is labelled with His tag.

Purpose: Recombinant Human CDH10 protein with C-terminal 6xHis tag

Specificity: CDH10 (Gly55-Ala613) 6xHis tag

Characteristics: Extracellular Domain Protein

Purity: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: CDH10 (Cadherin 10, Type 2 (T2-Cadherin) (CDH10))

Alternative Name: CDH10 (CDH10 Products)

Synonyms: A830016G23Rik Protein, C030003B10Rik Protein, C030011H18Rik Protein, cadherin 10 Protein, Cdh10 Protein, CDH10 Protein

Background: CAD10
Description: This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients. [provided by RefSeq, Nov 2015]

Molecular Weight: predicted molecular mass of 63.0 kDa after removal of the signal peptide. The apparent molecular mass of CDH10-His is 70-130 kDa due to glycosylation.

UniProt: Q9Y6N8

Pathways: Cell-Cell Junction Organization