CCR1 Protein

Catalog No. ABIN7491555

Product Details

Target: CCR1 (Chemokine (C-C Motif) Receptor 1 (CCR1))

Protein Type: Synthetic

Origin: Human

Source: HEK-293 Cells

Purpose: Human CCR1 full length protein-synthetic nanodisc

Characteristics: Full Length Transmembrane Proteins (synthetic Nanodisc)

Application Details

Application Notes:

• Applications for VLPs:
• ELISA
• SPR affinity analysis
• Phage display screening
• Immunization
• Cell based assays
• CAR-T cell screening
• Protein cystal structure analysis

Comment:

Synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied in nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0)

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: CCR1 (Chemokine (C-C Motif) Receptor 1 (CCR1))

Alternative Name: CCR1 (CCR1 Products)

Synonyms: CD191 Protein, CKR-1 Protein, CKR1 Protein, CMKBR1 Protein, HM145 Protein, MIP1aR Protein, SCYAR1 Protein, Cmkbr1 Protein, Mip-1a-R Protein, C-C motif chemokine receptor 1 Protein, chemokine (C-C motif) receptor 1 Protein, CCR1 Protein, Ccr1 Protein

Background: CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1
Description: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

Molecular Weight: The human full length CCR1 protein has a MW of 41.2 kDa

UniProt: P32246